Across TCGA cell cohorts, L1CAM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible L1CAM-associated GO terms across cancer lineages are Protein-containing complex disassembly, Positive regulation of cell growth, and Type 2 mitophagy. Each is linked with L1CAM in more than 11 cancer types. Because this analysis shows association rather than direction, both L1CAM-to-partner and partner-to-L1CAM results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (L1CAM→partner) and Y-score (partner→L1CAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein-containing complex disassembly →	+0.075	+2.860	<.001	.007	2	12
BREAST	Positive regulation of cell growth →	+0.057	+2.778	.009	<.001	3	10
OESOPHAGUS	Type 2 mitophagy →	+0.154	+2.314	.001	.001	3	10
LUNG_NSCLC_LUSC	Negative regulation of cilium assembly →	+0.080	+2.915	.007	.005	3	10
BREAST	Positive regulation of fibroblast proliferation →	+0.157	+3.408	<.001	<.001	3	9
OVARY	Regulation of protein modification by small protein conjugation or removal →	+0.057	+2.595	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,112 associations by consensus.

Exploration

L1CAM survival (RNA) · tumor vs normal (RNA) · all L1CAM data types