KYAT3

Across TCGA pan-cancer cohorts, KYAT3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KYAT3 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KYAT3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KYAT3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where KYAT3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.903	0.607	.001	53	view →
PDAC	DFS	Quartile	II,III,IV	0.622	0.326	.002	28	view →
LUAD	DFS	Median	All	0.850	0.633	.001	18	view →
CCRCC	DFS	Quartile	III,IV	0.624	0.253	.015	13	view →
COAD	DFS	Median	III,IV	1.000	0.844	.044	6	view →
GBM	DFS	Median	All	0.270	0.470	.030	4	view →
LSCC	OS	Quartile	All	0.921	0.764	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KYAT3–HNSC (DFS)

Open the HNSC breakdown →