KY

Across TCGA pan-cancer cohorts, KY Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KY data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KY Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KY expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, LIHC, and STAD are the cancer types where KY Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.968	0.610	.006	28	view →
LIHC	DFS	Median	All	0.140	0.548	<.001	24	view →
STAD	OS	Median	All	1.000	0.651	.027	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	III,IV	1.000	0.690	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KY–UCEC (DFS)

Open the UCEC breakdown →