KTN1

Across TCGA patient cohorts, KTN1 mutation is significantly associated with the RNA expression of many other genes, with 2,637 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KTN1-associated genes across cancer lineages are C12orf43, SEC13, and NLRX1. Each is linked with KTN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KTN1-to-partner and partner-to-KTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf43 grouped by KTN1-low versus KTN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KTN1→partner) and Y-score (partner→KTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C12orf43 →	+0.226	+2.321	.001	<.001	3	4
UCEC	SEC13 →	+0.399	+1.632	<.001	<.001	3	3
UCEC	NLRX1 →	+0.404	+2.364	.001	.002	3	3
UCEC	PHB →	+0.347	+1.632	.007	<.001	3	3
UCEC	GLOD4 →	+0.526	+2.290	<.001	<.001	3	3
UCEC	LSM3 →	+0.334	+1.632	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,637 associations by consensus.

C12orf43 by KTN1 expression — UCEC

Explore this box plot interactively →