KTN1

Across TCGA patient cohorts, KTN1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KTN1-associated genes across cancer lineages are ATM, Chk1, and INPP4B. Each is linked with KTN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KTN1-to-partner and partner-to-KTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KTN1-low versus KTN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KTN1→partner) and Y-score (partner→KTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.389	-1.473	.005	.006	3	4
COAD	Chk1 →	+0.385	+2.815	.001	.036	3	2
UCEC	INPP4B →	-0.293	-2.999	.003	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-2.247	.001	.001	3	2
UCEC	Shc_pY317 →	-0.161	-1.700	<.001	.001	3	2
UCEC	c-Kit →	-0.205	-1.700	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by KTN1 expression — UCEC

Explore this box plot interactively →