KTN1

Across TCGA cell cohorts, KTN1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KTN1-associated genes across cancer lineages are IFNL2, FAM236A, and OR2V1. Each is linked with KTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KTN1-to-partner and partner-to-KTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNL2 grouped by KTN1-low versus KTN1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KTN1→partner) and Y-score (partner→KTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IFNL2 →	+0.024	+4.437	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.090	+4.357	<.001	.006	3	2
LARGE_INTESTINE	OR2V1 →	+0.039	+2.925	<.001	.007	3	2
URINARY_TRACT	MMD2 →	+0.063	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUSC	CCDC140 →	+0.083	+4.643	.001	.008	3	1
LUNG_NSCLC_LUSC	OTC →	+0.033	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

IFNL2 by KTN1 expression — SKIN

Explore this box plot interactively →