KSR2

Across TCGA pan-cancer cohorts, KSR2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KSR2 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KSR2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KSR2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where KSR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.829	0.428	.001	17	view →
HNSC	OS	Tertile	III,IV	0.330	1.000	.024	6	view →
PDAC	OS	Median	III,IV	0.173	0.908	.003	6	view →
LSCC	DFS	Median	III,IV	0.821	0.427	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KSR2–LUAD (OS)

Open the LUAD breakdown →