KSR2

Across TCGA patient cohorts, KSR2 mutation is significantly associated with the RNA expression of many other genes, with 5,349 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KSR2-associated genes across cancer lineages are CHAF1A, AUNIP, and EIF5A. Each is linked with KSR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both KSR2-to-partner and partner-to-KSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by KSR2-low versus KSR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KSR2→partner) and Y-score (partner→KSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.524	+1.794	<.001	<.001	3	5
UCEC	AUNIP →	+0.474	+1.592	<.001	.001	3	5
STAD	EIF5A →	+0.628	+3.840	<.001	<.001	3	5
UCEC	FCER1A →	-0.732	-1.932	<.001	<.001	3	5
UCEC	WDHD1 →	+0.429	+2.091	.001	<.001	3	5
UCEC	CENPU →	+0.487	+1.628	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,349 associations by consensus.

CHAF1A by KSR2 expression — UCEC

Explore this box plot interactively →