KSR2

Across TCGA cell cohorts, KSR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,339 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible KSR2-associated GO terms across cancer lineages are Regulation of DNA recombination, Regulation of myoblast fusion, and Cytoplasmic translation. Each is linked with KSR2 in more than 10 cancer types. Because this analysis shows association rather than direction, both KSR2-to-partner and partner-to-KSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA recombination grouped by KSR2-low versus KSR2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KSR2→partner) and Y-score (partner→KSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA recombination →	+0.060	+0.175	<.001	.001	3	10
LUNG_SCLC	Regulation of myoblast fusion →	+0.108	+1.878	<.001	<.001	3	10
OVARY	Cytoplasmic translation →	+0.058	+0.215	.009	.001	2	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.079	+0.205	.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.066	+0.216	<.001	.001	3	9
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.107	+1.286	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,339 associations by consensus.

Regulation of DNA recombination by KSR2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →