KSR2

Across TCGA cell cohorts, KSR2 mutation is significantly associated with the RNA expression of many other genes, with 904 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KSR2-associated genes across cancer lineages are ZC3HAV1L, H2AZ1, and SLC2A11. Each is linked with KSR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KSR2-to-partner and partner-to-KSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC3HAV1L grouped by KSR2-low versus KSR2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KSR2→partner) and Y-score (partner→KSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZC3HAV1L →	+1.211	+3.215	.007	.005	3	3
BLOOD_Leukemia	H2AZ1 →	+0.654	+3.378	<.001	.005	3	3
LARGE_INTESTINE	SLC2A11 →	+0.842	+2.714	.002	.002	3	3
BLOOD_Leukemia	BCL7A →	+1.277	+3.199	.007	.007	2	3
BLOOD_Leukemia	DCLRE1B →	+0.556	+3.199	.006	.007	3	2
BLOOD_Leukemia	NCAPH →	+0.645	+3.199	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 904 associations by consensus.

ZC3HAV1L by KSR2 expression — BLOOD_Leukemia

Explore this box plot interactively →