KSR1

Across TCGA pan-cancer cohorts, KSR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KSR1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KSR1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KSR1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where KSR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.631	0.947	.017	11	view →
UCEC	OS	Quartile	III,IV	0.288	1.000	.027	4	view →
PDAC	OS	Tertile	II,III,IV	0.271	0.508	.036	2	view →
LUAD	OS	Tertile	III,IV	0.225	0.654	.032	2	view →
GBM	OS	Quartile	All	0.631	0.330	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KSR1–CCRCC (OS)

Open the CCRCC breakdown →