KSR1

Across TCGA patient cohorts, KSR1 mutation is significantly associated with the RNA expression of many other genes, with 4,197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KSR1-associated genes across cancer lineages are RPL23AP82, NDUFA6, and FAF1. Each is linked with KSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KSR1-to-partner and partner-to-KSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by KSR1-low versus KSR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KSR1→partner) and Y-score (partner→KSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP82 →	+0.624	+3.836	<.001	<.001	3	3
UCEC	NDUFA6 →	+0.446	+1.958	<.001	<.001	3	3
UCEC	FAF1 →	+0.333	+2.343	<.001	<.001	3	3
UCEC	LONP1 →	+0.668	+2.233	<.001	<.001	3	3
UCEC	MCMBP →	+0.437	+2.008	<.001	.001	3	3
UCEC	PRC1 →	+0.741	+2.839	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,197 associations by consensus.

RPL23AP82 by KSR1 expression — SKCM

Explore this box plot interactively →