KSR1

Across TCGA patient cohorts, KSR1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KSR1-associated genes across cancer lineages are ATM, Claudin-7, and FoxM1. Each is linked with KSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KSR1-to-partner and partner-to-KSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KSR1-low versus KSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KSR1→partner) and Y-score (partner→KSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.487	-3.687	.001	.001	3	3
COAD	Claudin-7 →	+0.672	+3.178	.040	.010	3	2
UCEC	FoxM1 →	+0.247	+2.710	.005	.003	3	2
UCEC	Rab25 →	-0.308	-2.115	.006	.016	3	2
UCEC	Rad50 →	-0.241	-3.687	.003	.001	3	2
UCEC	ASNS →	+0.340	+2.321	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by KSR1 expression — UCEC

Explore this box plot interactively →