KSR1

Across TCGA cell cohorts, KSR1 mutation is significantly associated with the RNA expression of many other genes, with 220 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KSR1-associated genes across cancer lineages are GHRH, BOD1L2, and CPN1. Each is linked with KSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KSR1-to-partner and partner-to-KSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by KSR1-low versus KSR1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KSR1→partner) and Y-score (partner→KSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
OESOPHAGUS	BOD1L2 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Leukemia	CPN1 →	+0.101	+3.820	.002	.004	3	1
BLOOD_Leukemia	SLITRK3 →	+0.029	+3.289	<.001	.009	3	1
BLOOD_Leukemia	NGF →	+0.263	+3.594	.001	.007	3	1
BLOOD_Leukemia	CYP39A1 →	+0.173	+4.091	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 220 associations by consensus.

GHRH by KSR1 expression — OESOPHAGUS

Explore this box plot interactively →