Across TCGA patient cohorts, KRTAP5-3 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KRTAP5-3-associated genes across cancer lineages are RAD1, NTAN1, and DIRAS3. Each is linked with KRTAP5-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-3-to-partner and partner-to-KRTAP5-3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-3→partner) and Y-score (partner→KRTAP5-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RAD1 →	+0.621	+2.758	<.001	.002	3	2
SKCM	NTAN1 →	+0.464	+2.732	.001	.003	3	2
SKCM	DIRAS3 →	+0.850	+2.706	<.001	.003	3	2
UCEC	RNA5SP223 →	+0.342	+3.997	<.001	.009	3	2
SKCM	PBK →	+0.878	+2.719	.005	.003	3	2
OV	SNRPGP19 →	+1.018	+4.991	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

Exploration

KRTAP5-3 survival (RNA) · tumor vs normal (RNA) · all KRTAP5-3 data types