Across TCGA pan-cancer cohorts, KRTAP5-2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KRTAP5-2 data layer compared with 3 for mutation status.

The strongest signal is observed in thymoma (THYM), where higher KRTAP5-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP5-2 expression acts as an unfavorable survival marker, although some lineages such as CESC and SCLC show a favorable association.

THYM, ESCA, and ACC are the cancer types where KRTAP5-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.756	0.981	<.001	78	view →
ESCA	OS	Median	All	0.504	1.000	.001	31	view →
ACC	OS	Tertile	All	0.472	0.840	.003	27	view →
LUAD	DFS	Tertile	IV	0.478	0.783	.006	26	view →
SKCM	OS	Tertile	II,III,IV	0.151	0.453	.001	24	view →
MESO	OS	Tertile	IV	0.077	0.638	<.001	24	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	24	view →
CESC	OS	Tertile	II,III,IV	0.943	0.786	.017	24	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	18	view →
LGG	OS	Tertile	All	0.714	0.851	.014	15	view →
SCLC	DFS	Median	IV	0.630	0.164	.022	13	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

Exploration

Same gene, other analysis: KRTAP5-2 tumor-vs-normal RNA expression · all KRTAP5-2 data types