Across TCGA patient cohorts, KRTAP4-9 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-9-associated genes across cancer lineages are Caspase-8, MEK1, and Notch1. Each is linked with KRTAP4-9 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-9-to-partner and partner-to-KRTAP4-9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-9→partner) and Y-score (partner→KRTAP4-9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.269	-3.143	.026	.018	3	2
UCEC	MEK1 →	+0.401	+3.000	.023	.036	3	1
UCEC	Notch1 →	+0.178	+3.009	.009	.019	3	1
UCEC	Annexin-1 →	+0.723	+2.827	.004	.035	3	1
UCEC	Tuberin →	+0.351	+3.584	.007	.002	3	1
UCEC	ATM →	-0.509	-2.459	.020	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

KRTAP4-9 survival (RNA) · tumor vs normal (RNA) · all KRTAP4-9 data types