Across TCGA pan-cancer cohorts, KRTAP4-8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KRTAP4-8 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KRTAP4-8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP4-8 expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

UCEC, SKCM, and TGCT are the cancer types where KRTAP4-8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
SKCM	OS	Median	All	0.249	0.781	.011	12	view →
TGCT	DFS	Median	II,III,IV	0.088	0.917	.010	6	view →
BRCA	DFS	Median	All	0.112	0.526	.005	6	view →
SCLC	DFS	Median	All	1.000	0.461	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: KRTAP4-8 tumor-vs-normal RNA expression · all KRTAP4-8 data types