KRTAP4-4

Across TCGA pan-cancer cohorts, KRTAP4-4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KRTAP4-4 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher KRTAP4-4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP4-4 expression acts as an unfavorable survival marker.

SCLC, DLBC, and LIHC are the cancer types where KRTAP4-4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.137	0.700	<.001	48	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
LIHC	OS	Median	All	0.188	0.669	.041	6	view →
PRAD	OS	Median	All	0.740	0.990	<.001	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KRTAP4-4–SCLC (OS)

Open the SCLC breakdown →