Across TCGA patient cohorts, KRTAP4-1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-1-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Fibronectin. Each is linked with KRTAP4-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-1-to-partner and partner-to-KRTAP4-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-1→partner) and Y-score (partner→KRTAP4-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.291	-2.999	.012	.035	3	1
UCEC	ERK2 →	+0.236	+3.000	.008	.036	3	1
UCEC	Fibronectin →	-0.302	-2.312	.049	.034	3	1
UCEC	Rab25 →	-0.412	-2.584	.007	.011	3	1
UCEC	Annexin-1 →	+0.871	+3.479	<.001	.002	3	1
UCEC	Shc_pY317 →	-0.168	-2.584	.017	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

KRTAP4-1 survival (RNA) · tumor vs normal (RNA) · all KRTAP4-1 data types