Across TCGA pan-cancer cohorts, KRTAP27-1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KRTAP27-1 data layer compared with 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP27-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP27-1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, COAD, and SKCM are the cancer types where KRTAP27-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.041	0.759	<.001	36	view →
COAD	OS	Median	All	0.532	0.874	<.001	24	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	15	view →
UCEC	DFS	Median	All	1.000	0.829	.018	8	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: KRTAP27-1 tumor-vs-normal RNA expression · all KRTAP27-1 data types