KRTAP27-1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KRTAP27-1 mutation is significantly associated with the RNA expression of many other genes, with 552 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP27-1-associated genes across cancer lineages are HDGFL2, ELP5, and HRAS. Each is linked with KRTAP27-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP27-1-to-partner and partner-to-KRTAP27-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP27-1→partner) and Y-score (partner→KRTAP27-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECHDGFL2 →+0.415+2.700.004.00632
UCECELP5 →+0.339+3.385.009.00432
UCECHRAS →+0.409+2.087.007.00632
LUADIGHD6-19 →+1.528+3.051<.001.00532
HNSCRPL7L1P13 →+0.075+4.654<.001.00432
LUSCPYY3 →+0.295+5.906<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 552 associations by consensus.

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