Across TCGA patient cohorts, KRTAP27-1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP27-1-associated genes across cancer lineages are C-Raf, A-Raf_pS299, and ERK2. Each is linked with KRTAP27-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP27-1-to-partner and partner-to-KRTAP27-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP27-1→partner) and Y-score (partner→KRTAP27-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.155	+2.584	.005	.010	3	2
UCEC	A-Raf_pS299 →	-0.135	-2.321	.003	.034	3	1
UCEC	ERK2 →	+0.215	+3.700	.004	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-1.986	.002	.010	3	1
UCEC	JNK2 →	+0.160	+1.584	.040	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.413	-2.000	.025	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

KRTAP27-1 survival (RNA) · tumor vs normal (RNA) · all KRTAP27-1 data types