KRTAP25-1

Across TCGA pan-cancer cohorts, KRTAP25-1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KRTAP25-1 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher KRTAP25-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP25-1 expression acts as an unfavorable survival marker.

ESCA and ACC are the cancer types where KRTAP25-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.212	0.686	.008	30	view →
ACC	OS	Median	All	0.113	0.822	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

KRTAP25-1–ESCA (OS)

Open the ESCA breakdown →