Across TCGA pan-cancer cohorts, KRTAP22-2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of KRTAP22-2’s most consistent transcriptional readouts.
The strongest signal is observed in prostate adenocarcinoma (PRAD), where KRTAP22-2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRTAP22-2 is over-expressed in tumor.
PRAD are the cancer types where KRTAP22-2 tumor–normal differential expression is most reproducible.