Across TCGA patient cohorts, KRTAP2-4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP2-4-associated genes across cancer lineages are MIR6859-2, MIR8087, and MIR5691. Each is linked with KRTAP2-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP2-4-to-partner and partner-to-KRTAP2-4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP2-4→partner) and Y-score (partner→KRTAP2-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6859-2 →	+0.657	+4.690	.001	.003	3	1
UCEC	MIR8087 →	+1.056	+4.398	<.001	.006	3	1
UCEC	MIR5691 →	+0.733	+6.279	<.001	<.001	3	1
UCEC	DMRTC1B →	+0.082	+4.302	<.001	.008	3	1
UCEC	RNA5SP393 →	+0.628	+4.936	<.001	.002	3	1
UCEC	GUSBP16 →	+0.093	+4.448	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

KRTAP2-4 survival (RNA) · tumor vs normal (RNA) · all KRTAP2-4 data types