KRTAP19-3

Across TCGA pan-cancer cohorts, KRTAP19-3 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated KRTAP19-3 data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP19-3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRTAP19-3 expression acts as an unfavorable survival marker, although some lineages such as UCS and SARC show a favorable association.

HNSC, STAD, and OV are the cancer types where KRTAP19-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.532	0.714	<.001	144	view →
STAD	OS	Tertile	IV	0.178	0.601	.012	36	view →
OV	OS	Tertile	IV	0.028	0.759	.002	36	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	36	view →
LAML	DFS	Tertile	All	0.140	0.575	.014	36	view →
SKCM	OS	Tertile	All	0.623	0.800	.002	30	view →
UCS	OS	Tertile	III,IV	0.879	0.487	.010	18	view →
PCPG	DFS	Tertile	All	0.067	0.857	<.001	18	view →
PRAD	OS	Tertile	All	0.157	0.883	<.001	18	view →
LUSC	OS	Tertile	All	0.222	0.414	.009	15	view →
SARC	DFS	Tertile	All	1.000	0.596	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

KRTAP19-3–HNSC (DFS)

Open the HNSC breakdown →