KRTAP13-3

Across TCGA patient cohorts, KRTAP13-3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP13-3-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and MEK1. Each is linked with KRTAP13-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP13-3-to-partner and partner-to-KRTAP13-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by KRTAP13-3-low versus KRTAP13-3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP13-3→partner) and Y-score (partner→KRTAP13-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.213	-3.446	.011	.005	3	1
UCEC	JNK2 →	+0.241	+2.321	.015	.035	3	1
UCEC	MEK1 →	+0.479	+3.459	.009	.005	3	1
UCEC	Notch1 →	+0.231	+2.179	.001	.034	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.624	-2.308	.005	.036	3	1
UCEC	PDCD4 →	-0.805	-3.160	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

JNK_pT183_Y185 by KRTAP13-3 expression — UCEC

Explore this box plot interactively →