Across TCGA pan-cancer cohorts, KRTAP13-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of KRTAP13-1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRTAP13-1 RNA is repressed in tumor relative to normal tissue. In most cancer types KRTAP13-1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.
HNSC and LUAD are the cancer types where KRTAP13-1 tumor–normal differential expression is most reproducible.