Across TCGA pan-cancer cohorts, KRTAP12-4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KRTAP12-4 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KRTAP12-4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP12-4 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC and GBM are the cancer types where KRTAP12-4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	8	view →
GBM	DFS	Median	All	1.000	0.204	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KRTAP12-4 tumor-vs-normal RNA expression · all KRTAP12-4 data types