Across TCGA pan-cancer cohorts, KRTAP12-3 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated KRTAP12-3 data layer compared with 3 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher KRTAP12-3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP12-3 expression acts as an unfavorable survival marker.

SCLC, UVM, and OV are the cancer types where KRTAP12-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.139	0.842	<.001	54	view →
UVM	OS	Tertile	III,IV	0.075	0.814	<.001	48	view →
OV	OS	Tertile	II,III,IV	0.696	0.848	.027	36	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
LAML	DFS	Tertile	All	0.287	0.497	.012	30	view →
ACC	OS	Tertile	II,III,IV	0.189	0.871	<.001	27	view →
THCA	DFS	Tertile	II,III,IV	0.514	0.885	.002	21	view →
STAD	OS	Tertile	IV	0.075	0.496	.013	18	view →
PCPG	DFS	Tertile	All	0.405	0.775	.022	18	view →
KICH	OS	Tertile	All	0.648	0.972	.012	9	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	9	view →
PAAD	OS	Tertile	All	0.200	0.589	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

Exploration

Same gene, other analysis: KRTAP12-3 tumor-vs-normal RNA expression · all KRTAP12-3 data types