Across TCGA pan-cancer cohorts, KRTAP12-2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of KRTAP12-2’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where KRTAP12-2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRTAP12-2 is over-expressed in tumor.
THCA are the cancer types where KRTAP12-2 tumor–normal differential expression is most reproducible.