Across TCGA pan-cancer cohorts, KRTAP12-1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated KRTAP12-1 data layer compared with 5 for mutation status.
The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KRTAP12-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP12-1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and HNSC show a favorable association.
LUAD, ESCA, and BRCA are the cancer types where KRTAP12-1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.