KRTAP10-7

Across TCGA patient cohorts, KRTAP10-7 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP10-7-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and JNK2. Each is linked with KRTAP10-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP10-7-to-partner and partner-to-KRTAP10-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KRTAP10-7-low versus KRTAP10-7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP10-7→partner) and Y-score (partner→KRTAP10-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.345	-3.321	.008	.010	3	1
UCEC	INPP4B →	-0.370	-3.000	.029	.036	3	1
UCEC	JNK2 →	+0.369	+3.009	<.001	.019	3	1
UCEC	PDCD4 →	-0.784	-3.321	.001	.010	3	1
UCEC	TFRC →	+0.783	+3.321	.004	.010	2	2
UCEC	C-Raf →	+0.159	+3.321	.034	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by KRTAP10-7 expression — UCEC

Explore this box plot interactively →