Across TCGA patient cohorts, KRTAP10-12 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP10-12-associated genes across cancer lineages are JNK_pT183_Y185, p70-S6K_pT389, and Annexin-1. Each is linked with KRTAP10-12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP10-12-to-partner and partner-to-KRTAP10-12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP10-12→partner) and Y-score (partner→KRTAP10-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.197	-3.169	.015	.019	3	1
UCEC	p70-S6K_pT389 →	-0.246	-3.169	.007	.018	3	1
UCEC	Annexin-1 →	+0.575	+2.459	.023	.020	3	1
UCEC	Shc_pY317 →	-0.226	-2.459	.002	.020	3	1
UCEC	Src_pY416 →	-0.249	-2.446	.032	.020	3	1
UCEC	c-Kit →	-0.222	-2.459	.049	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

KRTAP10-12 survival (RNA) · tumor vs normal (RNA) · all KRTAP10-12 data types