Across TCGA pan-cancer cohorts, KRTAP1-3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KRTAP1-3 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher KRTAP1-3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP1-3 expression acts as an unfavorable survival marker.

LUSC, UCEC, and LIHC are the cancer types where KRTAP1-3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.112	0.743	<.001	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	DFS	Median	All	0.043	0.543	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KRTAP1-3 tumor-vs-normal RNA expression · all KRTAP1-3 data types