Across TCGA pan-cancer cohorts, KRT8P51 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KRT8P51’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where KRT8P51 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT8P51 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.
BRCA, KIRC, and BLCA are the cancer types where KRT8P51 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT8P51 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.