Across TCGA pan-cancer cohorts, KRT8P28 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KRT8P28’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KRT8P28 RNA is repressed in tumor relative to normal tissue. In most cancer types KRT8P28 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.
KIRC, LUAD, and KIRP are the cancer types where KRT8P28 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT8P28 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.