Across TCGA pan-cancer cohorts, KRT8P26 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KRT8P26’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KRT8P26 RNA is repressed in tumor relative to normal tissue. In most cancer types KRT8P26 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.
KIRC, KICH, and LIHC are the cancer types where KRT8P26 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT8P26 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.