Across TCGA pan-cancer cohorts, KRT8P21 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KRT8P21’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KRT8P21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT8P21 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.

COAD, BRCA, and LUSC are the cancer types where KRT8P21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT8P21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.191	.013	6	view →
BRCA	All	II,III,IV	+0.027	.004	4	view →
LUSC	All	All	+0.031	.024	2	view →
LIHC	Male	II,III,IV	−0.016	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KRT8P21 RNA expression & survival · all KRT8P21 data types