KRT86

Across TCGA pan-cancer cohorts, KRT86 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated KRT86 data layer compared with 6 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher KRT86 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KRT86 expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

SCLC, SKCM, and LUAD are the cancer types where KRT86 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.713	0.336	.001	67	view →
SKCM	DFS	Tertile	II,III,IV	0.350	0.154	.001	62	view →
LUAD	DFS	Quartile	All	0.358	0.567	.001	37	view →
OV	OS	Tertile	IV	0.464	0.758	.012	34	view →
MESO	OS	Tertile	All	0.398	0.641	.002	30	view →
HNSC	DFS	Median	IV	0.719	0.565	.003	17	view →
ACC	DFS	Tertile	IV	0.646	0.193	.006	14	view →
LUSC	OS	Tertile	All	0.596	0.741	.012	13	view →
PAAD	OS	Quartile	II,III,IV	0.463	0.743	.006	12	view →
KIRC	DFS	Quartile	III,IV	0.510	0.206	.038	12	view →
ESCA	OS	Tertile	IV	0.219	0.864	.024	12	view →
THYM	DFS	Tertile	All	0.922	0.635	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

KRT86–SCLC (OS)

Open the SCLC breakdown →