KRT84

Across TCGA pan-cancer cohorts, KRT84 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated KRT84 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher KRT84 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRT84 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, KICH, and UCEC are the cancer types where KRT84 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.703	<.001	36	view →
KICH	DFS	Median	All	0.043	0.971	<.001	27	view →
UCEC	DFS	Median	All	1.000	0.629	.024	14	view →
GBM	OS	Median	All	0.030	0.416	<.001	6	view →
SARC	OS	Median	All	0.156	0.767	.001	6	view →
COAD	DFS	Median	III,IV	0.167	0.565	.007	6	view →
LIHC	DFS	Median	All	0.096	0.526	.023	6	view →
LUSC	OS	Median	II,III,IV	0.304	0.633	.039	5	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUAD	DFS	Median	All	0.213	0.676	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

KRT84–ESCA (OS)

Open the ESCA breakdown →