KRT84

Across TCGA patient cohorts, KRT84 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT84-associated genes across cancer lineages are INPP4B, PCNA, and Caspase-7-cleavedD198. Each is linked with KRT84 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT84-to-partner and partner-to-KRT84 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by KRT84-low versus KRT84-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT84→partner) and Y-score (partner→KRT84) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.326	-2.794	.021	.003	3	2
UCEC	PCNA →	+0.228	+2.321	.015	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.660	+2.341	.010	.019	3	2
UCEC	Cyclin-B1 →	+0.567	+2.115	.020	.019	3	2
UCEC	EGFR_pY1068 →	-0.284	-3.321	.009	.010	3	1
UCEC	HER3 →	+0.318	+1.598	.008	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

INPP4B by KRT84 expression — UCEC

Explore this box plot interactively →