Across TCGA patient cohorts, KRT81 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT81-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and MEK1. Each is linked with KRT81 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT81-to-partner and partner-to-KRT81 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT81→partner) and Y-score (partner→KRT81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.298	-3.169	.013	.019	3	1
UCEC	A-Raf_pS299 →	-0.119	-3.000	.040	.036	3	1
UCEC	MEK1 →	+0.395	+3.584	.025	.002	3	1
UCEC	p62 Lck ligand →	+0.336	+2.179	.032	.034	3	1
UCEC	PDK1_pS241 →	+0.184	+3.000	.026	.036	3	1
UCEC	Annexin-1 →	+0.714	+2.827	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

KRT81 survival (RNA) · tumor vs normal (RNA) · all KRT81 data types