Across TCGA cell cohorts, KRT81 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRT81-associated genes across cancer lineages are MYL2, IFNG, and WFDC12. Each is linked with KRT81 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT81-to-partner and partner-to-KRT81 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT81→partner) and Y-score (partner→KRT81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYL2 →	+0.572	+4.152	<.001	.009	3	1
BLOOD_Leukemia	IFNG →	+0.228	+4.152	<.001	.009	3	1
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1
SKIN	GALNTL5 →	+0.029	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

KRT81 survival (RNA) · tumor vs normal (RNA) · all KRT81 data types