KRT80

Across TCGA patient cohorts, KRT80 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT80-associated genes across cancer lineages are ATM, p27_pT198, and Annexin-1. Each is linked with KRT80 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT80-to-partner and partner-to-KRT80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KRT80-low versus KRT80-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT80→partner) and Y-score (partner→KRT80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATM →	-0.580	-3.169	.003	.018	3	3
UCEC	p27_pT198 →	+0.092	+3.000	.032	.036	3	2
UCEC	Annexin-1 →	+0.734	+3.584	<.001	.002	3	2
SKCM	Bid →	+0.341	+2.321	<.001	.035	3	2
UCEC	14-3-3_beta →	-0.100	-3.295	.013	.009	3	1
UCEC	JNK2 →	+0.219	+1.906	.006	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by KRT80 expression — SKCM

Explore this box plot interactively →