KRT80

Across TCGA cell cohorts, KRT80 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT80-associated genes across cancer lineages are CFHR2, ADAM2, and DEFB133. Each is linked with KRT80 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT80-to-partner and partner-to-KRT80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by KRT80-low versus KRT80-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT80→partner) and Y-score (partner→KRT80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
BLOOD_Leukemia	ADAM2 →	+0.105	+5.539	.001	.003	3	1
LUNG_NSCLC_LUAD	DEFB133 →	+0.080	+5.228	.005	.005	3	1
LARGE_INTESTINE	HTR3A →	+0.600	+3.392	.002	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CFHR2 by KRT80 expression — LARGE_INTESTINE

Explore this box plot interactively →