Across TCGA patient cohorts, KRT77 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT77-associated genes across cancer lineages are ASNS, PKC-a_pS657, and Caspase-7-cleavedD198. Each is linked with KRT77 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT77-to-partner and partner-to-KRT77 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT77→partner) and Y-score (partner→KRT77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.403	+2.321	.008	.034	3	2
SKCM	PKC-a_pS657 →	-0.468	-2.987	.011	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.513	+2.189	.041	.034	3	1
UCEC	4E-BP1 →	+0.302	+3.169	.008	.018	3	1
UCEC	JNK2 →	+0.238	+2.222	.004	.011	2	1
SKCM	Dvl3 →	-0.316	-2.459	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

KRT77 survival (RNA) · tumor vs normal (RNA) · all KRT77 data types