Across TCGA cell cohorts, KRT77 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT77-associated genes across cancer lineages are TGM7, SNTG2, and OR4F21. Each is linked with KRT77 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT77-to-partner and partner-to-KRT77 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT77→partner) and Y-score (partner→KRT77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TGM7 →	+0.013	+5.087	<.001	.004	3	1
LARGE_INTESTINE	SNTG2 →	+0.147	+4.052	<.001	<.001	3	1
LARGE_INTESTINE	OR4F21 →	+0.212	+4.141	<.001	<.001	3	1
LARGE_INTESTINE	RSC1A1 →	+0.932	+3.519	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

KRT77 survival (RNA) · tumor vs normal (RNA) · all KRT77 data types