Across TCGA pan-cancer cohorts, KRT76 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KRT76’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRT76 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types KRT76 is over-expressed in tumor, although a few such as HNSC and OV show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where KRT76 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT76 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−1.527	<.001	8	view →
PDAC	Female	All	+1.192	<.001	6	view →
LSCC	All	All	+0.638	<.001	4	view →
OV	All	All	−6.555	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KRT76 RNA expression & survival · all KRT76 data types